Haptoglobin Genotype Determines Myocardial Infarct Size in Diabetic Mice
نویسندگان
چکیده
منابع مشابه
Haptoglobin genotype determines myocardial infarct size in diabetic mice.
OBJECTIVES We sought to understand the importance of oxidative stress in explaining why the haptoglobin (Hp) genotype determines myocardial infarction (MI) size in diabetes mellitus (DM). BACKGROUND Two common alleles (1 and 2) exist at the Hp locus in humans. The Hp 2 allele is associated with increased MI size in individuals with DM. In vitro, the Hp 2 protein is associated with increased g...
متن کاملHaptoglobin genotype is a determinant of survival and cardiac remodeling after myocardial infarction in diabetic mice
BACKGROUND We have recently demonstrated in man that a functional allelic polymorphism in the Haptoglobin (Hp) gene plays a major role in determining survival and congestive heart failure after myocardial infarction (MI). We sought to recapitulate the effect of Hp type on outcomes and cardiac remodeling after MI in transgenic mice. METHODS The Hp 2 allele exists only in man. Wild type C57Bl/6...
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The mortality rate from myocardial infarction is disproportionately high in diabetic patients. One explanation for this may be that diabetic patients incur more extensive myocardial necrosis. This possibility was examined in a three part study. Firstly, peak serum aspartate aminotransferase concentrations of all diabetic and non-diabetic patients admitted with myocardial infarction over a 16 ye...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2007
ISSN: 0735-1097
DOI: 10.1016/j.jacc.2006.08.044